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Metabolic Syndrome 

Metabolic Syndrome

The mechanism surrounding insulin resistance is a biological/physiological evolutionary adaptation that humans and other animals have acquired over thousands of years. Prior to our industrial revolution, food was not plentiful. Humans adapted to periods of feast and famine through mechanisms whereby storage of energy in the form of fat tissue allowed for survival during times where food was scarce. This mechanism is affectionately known as the “Thrifty Gene Model”. Human genotypes developed with this as a benefit for survival.

Evolutionary Advances

Since the industrial revolution, humans have been able to feed continuously, so instead of gaining fat through carbohydrate storage mechanisms and then utilizing those storages for survival, we are now susceptible to accumulating both carbohydrate and fat in our bodies in an unregulated manner. Blood glucose overwhelms our insulin production and free glucose, and cholesterol starts to accumulate in unwelcome places such as arteries and organs. This in turn creates the environment for inflammatory changes and disease processes.

82% of Canadians

Don’t get enough exercise

40% of Canadians

Have high cholesterol levels

11.7 million Canadians

Have diabetes or prediabetes

The Spectrum of Disease

Insulin resistance leads to prediabetes, which leads to type two diabetes, which leads to metabolic syndrome. The spectrum of disease is the cornerstone for multiple chronic conditions, including heart attack/stroke, dementias, and hormone disruption, and is now associated with 13 different cancers.

All of us have a genetic predisposition to developing insulin resistance and the disease processes associated with it. Through exercise and dietary modifications, you can avoid the development of type two diabetes in most cases. Increasing your skeletal muscle and decreasing your body fat will help your metabolic processing of fats and carbohydrates.

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